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siVAE: interpretable deep generative models for single-cell transcriptomes

Neural networks such as variational autoencoders (VAE) perform dimensionality reduction for the visualization and analysis of genomic data, but are limited in their interpretability: it is unknown which data features are represented by each embedding dimension. We present siVAE, a VAE that is interp...

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Detalles Bibliográficos
Autores principales: Choi, Yongin, Li, Ruoxin, Quon, Gerald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940350/
https://www.ncbi.nlm.nih.gov/pubmed/36803416
http://dx.doi.org/10.1186/s13059-023-02850-y