TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation

BACKGROUND: TREM2 is a transmembrane receptor expressed by myeloid cells and acts to regulate their immune response. TREM2 governs the response of microglia to amyloid and tau pathologies in the Alzheimer’s disease (AD) brain. TREM2 is also present in a soluble form (sTREM2), and its CSF levels fluc...

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Detalles Bibliográficos
Autores principales: Moutinho, Miguel, Coronel, Israel, Tsai, Andy P., Di Prisco, Gonzalo Viana, Pennington, Taylor, Atwood, Brady K., Puntambekar, Shweta S., Smith, Daniel C., Martinez, Pablo, Han, Seonggyun, Lee, Younghee, Lasagna-Reeves, Cristian A., Lamb, Bruce T., Bissel, Stephanie J., Nho, Kwangsik, Landreth, Gary E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940368/
https://www.ncbi.nlm.nih.gov/pubmed/36805764
http://dx.doi.org/10.1186/s13073-023-01160-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940368/
https://www.ncbi.nlm.nih.gov/pubmed/36805764
http://dx.doi.org/10.1186/s13073-023-01160-z

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