Leukemogenic SHP2 mutations lead to erythropoietin independency of HCD-57 cells: a novel model for preclinical research of SHP2-mutant JMML

Leukemogenic SHP2 mutations occur in 35% of patients with juvenile myelomonocytic leukemia (JMML), a rare but fatal hematopoietic malignancy without representative cell models, which are urgently needed to investigate the pathogenesis and to develop novel therapeutic strategies. In this study, we es...

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Detalles Bibliográficos
Autores principales: Zhao, Yuming, He, Chunxiao, Zhang, Dengyang, Guo, Yao, Peng, Zhiyong, Yu, Liuting, Li, Na, Chen, Chun, Zhao, Zhizhuang Joe, Chen, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940371/
https://www.ncbi.nlm.nih.gov/pubmed/36805832
http://dx.doi.org/10.1186/s40164-023-00379-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940371/
https://www.ncbi.nlm.nih.gov/pubmed/36805832
http://dx.doi.org/10.1186/s40164-023-00379-1

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