Cargando…

Enhanced antitumor activity of a novel, oral, helper epitope-containing WT1 protein vaccine in a model of murine leukemia

BACKGROUND: A Wilms’ tumor 1 (WT1) oral vaccine, Bifidobacterium longum (B. longum) 420, in which the bacterium is used as a vector for WT1 protein, triggers immune responses through cellular immunity consisting of cytotoxic T lymphocytes (CTLs) and other immunocompetent cells (e.g., helper T cells)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Minagawa, Hikaru, Hashii, Yoshiko, Nakajima, Hiroko, Fujiki, Fumihiro, Morimoto, Soyoko, Nakata, Jun, Shirakawa, Toshiro, Katayama, Takane, Tsuboi, Akihiro, Ozono, Keiichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940413/ https://www.ncbi.nlm.nih.gov/pubmed/36803483 http://dx.doi.org/10.1186/s12885-023-10547-5

Ejemplares similares

An oral WT1 protein vaccine composed of WT1-anchored, genetically engineered Bifidobacterium longum allows for intestinal immunity in mice with acute myeloid leukemia
por: Nakagawa, Natsuki, et al.
Publicado: (2022)

Extremely strong infiltration of WT1-specific CTLs into mouse tumor by the combination vaccine with WT1-specific CTL and helper peptides
por: Nakata, Jun, et al.
Publicado: (2018)

Enhanced immune reaction resulting from co-vaccination of WT1 helper peptide assessed on PET-CT
por: Nakata, Jun, et al.
Publicado: (2020)

WT1 epitope-specific IgG and IgM antibodies for immune-monitoring in patients with advanced sarcoma treated with a WT1 peptide cancer vaccine
por: Alzaaqi, Shouq, et al.
Publicado: (2022)

Identification of a Novel C-Terminal Truncated WT1 Isoform with Antagonistic Effects against Major WT1 Isoforms
por: Tatsumi, Naoya, et al.
Publicado: (2015)

A phase I clinical study of a cocktail vaccine of Wilms’ tumor 1 (WT1) HLA class I and II peptides for recurrent malignant glioma
por: Tsuboi, Akihiro, et al.
Publicado: (2018)

Syndecan-4 as a biomarker to predict clinical outcome for glioblastoma multiforme treated with WT1 peptide vaccine
por: Takashima, Satoshi, et al.
Publicado: (2016)

Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide
por: Oji, Yusuke, et al.
Publicado: (2016)

Imaging Assessment of Tumor Response in the Era of Immunotherapy
por: Nakata, Jun, et al.
Publicado: (2021)

Cellular and Humoral Immune Responses Induced by an HLA Class I–restricted Peptide Cancer Vaccine Targeting WT1 Are Associated With Favorable Clinical Outcomes in Advanced Ovarian Cancer
por: Nishida, Sumiyuki, et al.
Publicado: (2022)

Encouraging Clinical Evolution of a Pediatric Patient With Relapsed Diffuse Midline Glioma Who Underwent WT1-Targeting Immunotherapy: A Case Report and Literature Review
por: Hashii, Yoshiko, et al.
Publicado: (2020)

An oral cancer vaccine using a Bifidobacterium vector suppresses tumor growth in a syngeneic mouse bladder cancer model
por: Kitagawa, Koichi, et al.
Publicado: (2021)

WT1 Peptide Cancer Vaccine for Patients with Hematopoietic Malignancies and Solid Cancers
por: Oka, Yoshihiro, et al.
Publicado: (2007)

An Immunocompetent Mouse Model for MLL/AF9 Leukemia Reveals the Potential of Spontaneous Cytotoxic T-Cell Response to an Antigen Expressed in Leukemia Cells
por: Hasegawa, Kana, et al.
Publicado: (2015)

Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity
por: Morimoto, Soyoko, et al.
Publicado: (2018)

WT1 Trio Peptide-Based Cancer Vaccine for Rare Cancers Expressing Shared Target WT1
por: Oji, Yusuke, et al.
Publicado: (2023)

Antitumor effect of oral cancer vaccine with Bifidobacterium delivering WT1 protein to gut immune system is superior to WT1 peptide vaccine
por: Shirakawa, Toshiro, et al.
Publicado: (2017)

Establishment of a novel NFAT-GFP reporter platform useful for the functional avidity maturation of HLA class II-restricted TCRs
por: Fujiki, Fumihiro, et al.
Publicado: (2023)

T Cell-Intrinsic Vitamin A Metabolism and Its Signaling Are Targets for Memory T Cell-Based Cancer Immunotherapy
por: Fujiki, Fumihiro, et al.
Publicado: (2022)

Distinct difference in tumor-infiltrating immune cells between Wilms’ tumor gene 1 peptide vaccine and anti-programmed cell death-1 antibody therapies
por: Yokota, Chisato, et al.
Publicado: (2021)

Immune adjuvant therapy using Bacillus Calmette–Guérin cell wall skeleton (BCG-CWS) in advanced malignancies: A phase 1 study of safety and immunogenicity assessments
por: Nishida, Sumiyuki, et al.
Publicado: (2019)

Glycosylation Status of CD43 Protein Is Associated with Resistance of Leukemia Cells to CTL-Mediated Cytolysis
por: Hasegawa, Kana, et al.
Publicado: (2016)

Longitudinal observation of serum anti-Müllerian hormone in three girls after cancer treatment
por: Miyoshi, Yoko, et al.
Publicado: (2016)

Wilms Tumor Gene (WT1) Peptide–based Cancer Vaccine Combined With Gemcitabine for Patients With Advanced Pancreatic Cancer
por: Nishida, Sumiyuki, et al.
Publicado: (2014)

B cell helper factors. I. Requirement for both interleukin 2 and another 40,000 mol wt factor
Publicado: (1981)

Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus
Publicado: (1996)

Epitopes associated with MHC restriction site of T cells. III. I-J epitope on MHC-restricted T helper cells
Publicado: (1987)

Frequent associations between CTL and T-Helper epitopes in HIV-1 genomes and implications for multi-epitope vaccine designs
por: Paul, Sinu, et al.
Publicado: (2010)

Immunogenic Consensus Sequence T helper Epitopes for a Pan-Burkholderia Biodefense Vaccine
por: De Groot, Anne S., et al.
Publicado: (2011)

Helper T Cell Epitope-Mapping Reveals MHC-Peptide Binding Affinities That Correlate with T Helper Cell Responses to Pneumococcal Surface Protein A
por: Singh, Rajesh, et al.
Publicado: (2010)

Phenotypes of a family with XLH with a novel PHEX mutation
por: Yamamoto, Akiko, et al.
Publicado: (2020)

Prevalence of Pseudohypoparathyroidism and Nonsurgical Hypoparathyroidism in Japan in 2017: A Nationwide Survey
por: Takatani, Rieko, et al.
Publicado: (2023)

Identification and characterization of T helper cell epitopes of the major outer membrane protein of Chlamydia trachomatis
Publicado: (1990)

Review of the Results of WT1 Peptide Vaccination Strategies for Myelodysplastic Syndromes and Acute Myeloid Leukemia from Nine Different Studies
por: Di Stasi, Antonio, et al.
Publicado: (2015)

Helper cell-independent antitumor activity of potent CD8(+) T cell epitope peptide vaccines is dependent upon CD40L
por: Llopiz, Diana, et al.
Publicado: (2013)

Understanding CD8(+) T-cell responses toward the native and alternate HLA-A*02:01-restricted WT1 epitope
por: Nguyen, Thi HO, et al.
Publicado: (2017)

A novel B- and helper T-cell epitopes-based prophylactic vaccine against Echinococcus granulosus
por: Pourseif, Mohammad M., et al.
Publicado: (2018)

A versatile T cell-based assay to assess therapeutic antigen-specific PD-1-targeted approaches
por: Versteven, Maarten, et al.
Publicado: (2018)

WT1 peptide analogue WT1-126Y enhances leukemia lysis
por: Alqudaihi, Ghofran, et al.
Publicado: (2014)

A conjoined universal helper epitope can unveil antitumor effects of a neoantigen vaccine targeting an MHC class I-restricted neoepitope
por: Swartz, Adam M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7dovk2c6hmd5qhovqa2iq7abm2