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Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats

INTRODUCTION: Recent studies have demonstrated that sodium-glucose co-transporter-2 inhibitors (SGLT2-i) reduce the risk of atrial fibrillation (AF) in patients with diabetes mellitus (DM), in which oxidative stress due to increased reactive oxygen species (ROS) contributes to the pathogenesis of AF...

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Detalles Bibliográficos
Autores principales: Koizumi, Takuya, Watanabe, Masaya, Yokota, Takashi, Tsuda, Masumi, Handa, Haruka, Koya, Jiro, Nishino, Kotaro, Tatsuta, Daishiro, Natsui, Hiroyuki, Kadosaka, Takahide, Koya, Taro, Nakao, Motoki, Hagiwara, Hikaru, Kamada, Rui, Temma, Taro, Tanaka, Shinya, Anzai, Toshihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940756/
https://www.ncbi.nlm.nih.gov/pubmed/36815024
http://dx.doi.org/10.3389/fcvm.2023.1005408