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Computational assessment of the impact of Cu(II) and Al(III) on β-amyloid(42) fibrils: Binding sites, structural stability, and possible physiological implications
One of Alzheimer’s disease major hallmarks is the aggregation of β-amyloid peptide, a process in which metal ions play an important role. In the present work, an integrative computational study has been performed to identify the metal-binding regions and determine the conformational impact of Cu(II)...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940836/ https://www.ncbi.nlm.nih.gov/pubmed/36814794 http://dx.doi.org/10.3389/fnins.2023.1110311 |