Chemogenetic rectification of the inhibitory tone onto hippocampal neurons reverts autistic-like traits and normalizes local expression of estrogen receptors in the Ambra1+/- mouse model of female autism

Female, but not male, mice with haploinsufficiency for the proautophagic Ambra1 gene show an autistic-like phenotype associated with hippocampal circuits dysfunctions which include loss of parvalbuminergic interneurons (PV-IN), decrease in the inhibition/excitation ratio, and abundance of immature d...

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Detalles Bibliográficos
Autores principales: Pignataro, Annabella, Krashia, Paraskevi, De Introna, Margherita, Nobili, Annalisa, Sabetta, Annamaria, Stabile, Francesca, La Barbera, Livia, D’Addario, Sebastian Luca, Ventura, Rossella, Cecconi, Francesco, D’Amelio, Marcello, Ammassari-Teule, Martine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941573/
https://www.ncbi.nlm.nih.gov/pubmed/36804922
http://dx.doi.org/10.1038/s41398-023-02357-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941573/
https://www.ncbi.nlm.nih.gov/pubmed/36804922
http://dx.doi.org/10.1038/s41398-023-02357-x

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