NFATc2-dependent epigenetic downregulation of the TSC2/Beclin-1 pathway is involved in neuropathic pain induced by oxaliplatin

Neuropathic pain is a common dose-limiting side effect of oxaliplatin, which hampers the effective treatment of tumors. Here, we found that upregulation of transcription factor NFATc2 decreased the expression of Beclin-1, a critical molecule in autophagy, in the spinal dorsal horn, and contributed t...

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Detalles Bibliográficos
Autores principales: Liu, Meng, Mai, Jing-Wen, Luo, De-Xing, Liu, Guan-Xi, Xu, Ting, Xin, Wen-Jun, Lin, Su-Yan, Li, Zhen-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941598/
https://www.ncbi.nlm.nih.gov/pubmed/36733258
http://dx.doi.org/10.1177/17448069231158289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941598/
https://www.ncbi.nlm.nih.gov/pubmed/36733258
http://dx.doi.org/10.1177/17448069231158289

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