Reduced specificity for the local lymph node assay for lipophilic chemicals: Implications for the validation of new approach methods for skin sensitization

Meaningful and accurate reference data are crucial for the validation of New Approach Methodologies (NAMs) in toxicology. For skin sensitization, multiple reference datasets are available including human patch test data, guinea pig data and data from the mouse local lymph node assay (LLNA). When ass...

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Detalles Bibliográficos
Autores principales: Natsch, Andreas, Kleinstreuer, Nicole, Asturiol, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941753/
https://www.ncbi.nlm.nih.gov/pubmed/36608925
http://dx.doi.org/10.1016/j.yrtph.2023.105333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941753/
https://www.ncbi.nlm.nih.gov/pubmed/36608925
http://dx.doi.org/10.1016/j.yrtph.2023.105333

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