Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity

HIV-1 envelope (Env) conformation determines the susceptibility of infected CD4(+) T cells to antibody-dependent cellular cytotoxicity (ADCC). Upon interaction with CD4, Env adopts more “open” conformations, exposing ADCC epitopes. HIV-1 limits Env-CD4 interaction and protects infected cells against...

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Detalles Bibliográficos
Autores principales: Laumaea, Annemarie, Marchitto, Lorie, Ding, Shilei, Beaudoin-Bussières, Guillaume, Prévost, Jérémie, Gasser, Romain, Chatterjee, Debashree, Gendron-Lepage, Gabrielle, Medjahed, Halima, Chen, Hung-Ching, Smith, Amos B., Ding, Haitao, Kappes, John C., Hahn, Beatrice H., Kirchhoff, Frank, Richard, Jonathan, Duerr, Ralf, Finzi, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941794/
https://www.ncbi.nlm.nih.gov/pubmed/36640355
http://dx.doi.org/10.1016/j.celrep.2022.111983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941794/
https://www.ncbi.nlm.nih.gov/pubmed/36640355
http://dx.doi.org/10.1016/j.celrep.2022.111983

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