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Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity
HIV-1 envelope (Env) conformation determines the susceptibility of infected CD4(+) T cells to antibody-dependent cellular cytotoxicity (ADCC). Upon interaction with CD4, Env adopts more “open” conformations, exposing ADCC epitopes. HIV-1 limits Env-CD4 interaction and protects infected cells against...
Autores principales: | Laumaea, Annemarie, Marchitto, Lorie, Ding, Shilei, Beaudoin-Bussières, Guillaume, Prévost, Jérémie, Gasser, Romain, Chatterjee, Debashree, Gendron-Lepage, Gabrielle, Medjahed, Halima, Chen, Hung-Ching, Smith, Amos B., Ding, Haitao, Kappes, John C., Hahn, Beatrice H., Kirchhoff, Frank, Richard, Jonathan, Duerr, Ralf, Finzi, Andrés |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941794/ https://www.ncbi.nlm.nih.gov/pubmed/36640355 http://dx.doi.org/10.1016/j.celrep.2022.111983 |
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