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Imaging-Based In Situ Analysis of 5-Methylcytosine at Low Repetitive Single Gene Loci with Transcription-Activator-Like Effector Probes

[Image: see text] Transcription-activator-like effectors (TALEs) are programmable DNA binding proteins that can be used for sequence-specific, imaging-based analysis of cellular 5-methylcytosine. However, this has so far been limited to highly repetitive satellite DNA. To expand this approach to the...

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Detalles Bibliográficos
Autores principales: Jung, Anne, Munõz-López, Álvaro, Buchmuller, Benjamin C., Banerjee, Sudakshina, Summerer, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942090/
https://www.ncbi.nlm.nih.gov/pubmed/36693632
http://dx.doi.org/10.1021/acschembio.2c00857