Cargando…

PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6

PTEN encodes a tumor suppressor with lipid and protein phosphatase activities whose dysfunction has been implicated in melanomagenesis; less is known about how its phosphatases regulate melanoma metastasis. We demonstrate that PTEN expression negatively correlates with metastatic progression in huma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Yanlin, Dai, Meng, Huang, Liping, Chen, Weiping, Yu, Ellen, Mendoza, Arnulfo, Michael, Helen, Khanna, Chand, Bosenberg, Marcus, McMahon, Martin, Merlino, Glenn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942123/ https://www.ncbi.nlm.nih.gov/pubmed/36824269 http://dx.doi.org/10.1016/j.isci.2023.106070

Ejemplares similares

PTEN Dual Lipid- and Protein-Phosphatase Function in Tumor Progression
por: Liu, Anne, et al.
Publicado: (2022)

Using the single-cell imaging system and orthotropic footpad injection to establish mouse models for experimental and spontaneous melanoma metastasis
por: Yu, Yanlin, et al.
Publicado: (2023)

PERK mediates resistance to BRAF inhibition in melanoma with impaired PTEN
por: Qin, Yifei, et al.
Publicado: (2021)

Circular RNA circENTPD7 suppresses the accumulation of PTEN to promote cell proliferation in non-small cell lung cancer
por: Yu, Hongwei, et al.
Publicado: (2022)

Association of the ENPP1/ENTPD1 Polymorphisms in Hemodialysis Patients
por: Zhang, Xi, et al.
Publicado: (2021)

Deletion of Cd39/Entpd1 Results in Hepatic Insulin Resistance
por: Enjyoji, Keiichi, et al.
Publicado: (2008)

BRaf(V600E) cooperates with Pten silencing to elicit metastatic melanoma
por: Dankort, David, et al.
Publicado: (2009)

Role of the Phosphatase PTEN in Early Vascular Remodeling
por: Sedding, Daniel G., et al.
Publicado: (2013)

Identification of ENTPD8 and cytidine in pancreatic cancer by metabolomic and transcriptomic conjoint analysis
por: An, Yong, et al.
Publicado: (2018)

Identifying small molecule probes of ENTPD5 through high throughput screening
por: Durst, Matthew A., et al.
Publicado: (2019)

A novel circular RNA circENTPD7 contributes to glioblastoma progression by targeting ROS1
por: Zhu, Fei, et al.
Publicado: (2020)

Functional ENTPD1 Polymorphisms in African Americans With Diabetes and End-Stage Renal Disease
por: Friedman, David J., et al.
Publicado: (2009)

Limited TCR repertoire and ENTPD1 dysregulation mark late-stage COVID-19
por: Wang, Na, et al.
Publicado: (2021)

Functional analysis of the protein phosphatase activity of PTEN
por: Zhang, Xiaoqun Catherine, et al.
Publicado: (2012)

Knockdown of ENTPD5 inhibits tumor metastasis and growth via regulating the GRP78/p-eIF-2α/CHOP pathway in serous ovarian cancer
por: Chen, Xueping, et al.
Publicado: (2022)

Yeast model identifies ENTPD6 as a potential non-obstructive azoospermia pathogenic gene
por: Wang, Qian, et al.
Publicado: (2015)

Deletion of ENTPD3 does not impair nucleotide hydrolysis in primary somatosensory neurons or spinal cord
por: McCoy, Eric, et al.
Publicado: (2014)

ENTPD5 Induces Apoptosis in Lung Cancer Cells via Regulating Caspase 3 Expression
por: Xue, Yijun, et al.
Publicado: (2015)

Interactions of Phosphatase and Tensin Homologue (PTEN) Proteins with Phosphatidylinositol Phosphates: Insights from Molecular Dynamics Simulations of PTEN and Voltage Sensitive Phosphatase
por: Kalli, Antreas C., et al.
Publicado: (2014)

Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis
por: Nogueira, Cristina, et al.
Publicado: (2010)

IGF-1R Inhibition Activates a YES/SFK Bypass Resistance Pathway: Rational Basis for Co-Targeting IGF-1R and Yes/SFK Kinase in Rhabdomyosarcoma()
por: Wan, Xiaolin, et al.
Publicado: (2015)

The ENTPD5/mt-PCPH oncoprotein is a catalytically inactive member of the ectonucleoside triphosphate diphosphohydrolase family
por: MacCARTHY, CAITLIN M., et al.
Publicado: ( 201)

The ectonucleotidase ENTPD1/CD39 limits biliary injury and fibrosis in mouse models of sclerosing cholangitis
por: Peng, Zhen‐Wei, et al.
Publicado: (2017)

ENTPD3 Marks Mature Stem Cell–Derived β-Cells Formed by Self-Aggregation In Vitro
por: Docherty, Fiona M., et al.
Publicado: (2021)

The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation
por: Xu, Lifen, et al.
Publicado: (2023)

A Role for ATF2 in Regulating MITF and Melanoma Development
por: Shah, Meera, et al.
Publicado: (2010)

Metabolomics uncovers a link between inositol metabolism and osteosarcoma metastasis
por: Ren, Ling, et al.
Publicado: (2017)

The protein phosphatase activity of PTEN is essential for regulating neural stem cell differentiation
por: Lyu, Jingwen, et al.
Publicado: (2015)

Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases
por: Miletic, Ana V., et al.
Publicado: (2010)

Differential Role of PTEN Phosphatase in Chemotactic Growth Cone Guidance
por: Henle, Steven J., et al.
Publicado: (2013)

A new case of spastic paraplegia type 64 due to a missense mutation in the ENTPD1 gene
por: Mamelona, Jean, et al.
Publicado: (2019)

Endothelial Effects of Simultaneous Expression of Human HO-1, E5NT, and ENTPD1 in a Mouse
por: Mierzejewska, Paulina, et al.
Publicado: (2023)

Igf2 ligand dependency of Pten(+/−) developmental and tumour phenotypes in the mouse
por: Church, D N, et al.
Publicado: (2012)

Ez-Metastasizing: The Crucial Roles of Ezrin in Metastasis
por: Buenaventura, Rand Gabriel M., et al.
Publicado: (2023)

Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity
por: Wong, J. T., et al.
Publicado: (2006)

PTEN inhibits BMI1 function independently of its phosphatase activity
por: Fan, Catherine, et al.
Publicado: (2009)

Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis
por: Stumpf, Miriam, et al.
Publicado: (2016)

Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes
por: Lee, Chang-Uk, et al.
Publicado: (2015)

PTEN Protein Phosphatase Activity Is Not Required for Tumour Suppression in the Mouse Prostate
por: Wise, Helen M., et al.
Publicado: (2022)

The Role of Oxidative Inactivation of Phosphatase PTEN and TCPTP in Fatty Liver Disease
por: Nguyen Huu, Thang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ikppbv5p41ph56mrkbkok7uiio