Photocatalysis and Kinetic Resolution by Lithiation to Give Enantioenriched 2-Arylpiperazines

[Image: see text] Piperazines are important heterocycles in drug compounds. We report the asymmetric synthesis of arylpiperazines by photocatalytic decarboxylative arylation (metallaphotoredox catalysis) then kinetic resolution using n-BuLi/(+)-sparteine. This gave a range of piperazines with very h...

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Detalles Bibliográficos
Autores principales: Das, Anjan, Choi, Anthony, Coldham, Iain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942196/
https://www.ncbi.nlm.nih.gov/pubmed/36735675
http://dx.doi.org/10.1021/acs.orglett.3c00074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942196/
https://www.ncbi.nlm.nih.gov/pubmed/36735675
http://dx.doi.org/10.1021/acs.orglett.3c00074

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