The CRISPR-Cas12a Platform for Accurate Genome Editing, Gene Disruption, and Efficient Transgene Integration in Human Immune Cells

[Image: see text] CRISPR-Cas12a nucleases have expanded the toolbox for targeted genome engineering in a broad range of organisms. Here, using a high-throughput engineering approach, we explored the potential of a novel CRISPR-MAD7 system for genome editing in human cells. We evaluated several thous...

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Detalles Bibliográficos
Autores principales: Mohr, Marina, Damas, Nkerorema, Gudmand-Høyer, Johanne, Zeeberg, Katrine, Jedrzejczyk, Dominika, Vlassis, Arsenios, Morera-Gómez, Martí, Pereira-Schoning, Sara, Puš, Urška, Oliver-Almirall, Anna, Lyholm Jensen, Tanja, Baumgartner, Roland, Tate Weinert, Brian, Gill, Ryan T., Warnecke, Tanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942205/
https://www.ncbi.nlm.nih.gov/pubmed/36750230
http://dx.doi.org/10.1021/acssynbio.2c00179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942205/
https://www.ncbi.nlm.nih.gov/pubmed/36750230
http://dx.doi.org/10.1021/acssynbio.2c00179

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