The Alzheimer’s disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130

BACKGROUND: The protease BACE1 is a major drug target for Alzheimer’s disease, but chronic BACE1 inhibition is associated with non-progressive cognitive worsening that may be caused by modulation of unknown physiological BACE1 substrates. METHODS: To identify in vivo-relevant BACE1 substrates, we ap...

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Detalles Bibliográficos
Autores principales: Müller, Stephan A., Shmueli, Merav D., Feng, Xiao, Tüshaus, Johanna, Schumacher, Neele, Clark, Ryan, Smith, Brad E., Chi, An, Rose-John, Stefan, Kennedy, Matthew E., Lichtenthaler, Stefan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942414/
https://www.ncbi.nlm.nih.gov/pubmed/36810097
http://dx.doi.org/10.1186/s13024-023-00596-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942414/
https://www.ncbi.nlm.nih.gov/pubmed/36810097
http://dx.doi.org/10.1186/s13024-023-00596-6

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