Bolaamphiphile Analogues of 12-bis-THA Cl(2) Are Potent Antimicrobial Therapeutics with Distinct Mechanisms of Action against Bacterial, Mycobacterial, and Fungal Pathogens

12-Bis-THA Cl(2) [12,12′-(dodecane-1,12-diyl)-bis-(9-amino-1,2,3,4-tetrahydroacridinium) chloride] is a cationic bolalipid adapted from dequalinium chloride (DQC), a bactericidal anti-infective indicated for bacterial vaginosis (BV). Here, we used a structure-activity-relationship study to show that...

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Detalles Bibliográficos
Autores principales: Di Blasio, Simona, Clarke, Maria, Hind, Charlotte K., Asai, Masanori, Laurence, Louis, Benvenuti, Angelica, Hassan, Mahnoor, Semenya, Dorothy, Man, DeDe Kwun-Wai, Horrocks, Victoria, Manzo, Giorgia, Van Der Lith, Sarah, Lam, Carolyn, Gentile, Eugenio, Annette, Callum, Bosse, Janine, Li, Yanwen, Panaretou, Barry, Langford, Paul R., Robertson, Brian D., Lam, Jenny K. W., Sutton, J. Mark, McArthur, Michael, Mason, A. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942557/
https://www.ncbi.nlm.nih.gov/pubmed/36511707
http://dx.doi.org/10.1128/msphere.00508-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942557/
https://www.ncbi.nlm.nih.gov/pubmed/36511707
http://dx.doi.org/10.1128/msphere.00508-22

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