Microencapsulated IL-12 Drives Genital Tract Immune Responses to Intranasal Gonococcal Outer Membrane Vesicle Vaccine and Induces Resistance to Vaginal Infection with Diverse Strains of Neisseria gonorrhoeae

An experimental gonococcal vaccine consisting of outer membrane vesicles (OMVs) and microsphere (ms)-encapsulated interleukin-12 (IL-12 ms) induces Th1-driven immunity, with circulating and genital antibodies to Neisseria gonorrhoeae, after intravaginal (i.vag.) administration in female mice, and ge...

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Detalles Bibliográficos
Autores principales: Liu, Yingru, Hammer, Laura A., Daamen, Jikke, Stork, Michiel, Egilmez, Nejat K., Russell, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942569/
https://www.ncbi.nlm.nih.gov/pubmed/36537786
http://dx.doi.org/10.1128/msphere.00388-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942569/
https://www.ncbi.nlm.nih.gov/pubmed/36537786
http://dx.doi.org/10.1128/msphere.00388-22

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