Mouse-Adapted SARS-CoV-2 MA10 Strain Displays Differential Pulmonary Tropism and Accelerated Viral Replication, Neurodissemination, and Pulmonary Host Responses in K18-hACE2 Mice

Several models were developed to study the pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as well as the in vivo efficacy of vaccines and therapeutics. Since wild-type mice are naturally resistant to infection by ancestral SARS-CoV-2 strains, several transgenic mouse m...

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Detalles Bibliográficos
Autores principales: Thieulent, Côme J., Dittmar, Wellesley, Balasuriya, Udeni B. R., Crossland, Nicholas A., Wen, Xue, Richt, Juergen A., Carossino, Mariano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942576/
https://www.ncbi.nlm.nih.gov/pubmed/36728430
http://dx.doi.org/10.1128/msphere.00558-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942576/
https://www.ncbi.nlm.nih.gov/pubmed/36728430
http://dx.doi.org/10.1128/msphere.00558-22

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