Downregulation of oxidative stress-mediated glial innate immune response suppresses seizures in a fly epilepsy model

Previous work in our laboratory has shown that mutations in prickle (pk) cause myoclonic-like seizures and ataxia in Drosophila, similar to what is observed in humans carrying mutations in orthologous PRICKLE genes. Here, we show that pk mutant brains show elevated, sustained neuronal cell death tha...

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Detalles Bibliográficos
Autores principales: Nukala, Krishna M., Lilienthal, Anthony J., Lye, Shu Hui, Bassuk, Alexander G., Chtarbanova, Stanislava, Manak, J. Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942582/
https://www.ncbi.nlm.nih.gov/pubmed/36641750
http://dx.doi.org/10.1016/j.celrep.2023.112004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942582/
https://www.ncbi.nlm.nih.gov/pubmed/36641750
http://dx.doi.org/10.1016/j.celrep.2023.112004

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