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Downregulation of oxidative stress-mediated glial innate immune response suppresses seizures in a fly epilepsy model
Previous work in our laboratory has shown that mutations in prickle (pk) cause myoclonic-like seizures and ataxia in Drosophila, similar to what is observed in humans carrying mutations in orthologous PRICKLE genes. Here, we show that pk mutant brains show elevated, sustained neuronal cell death tha...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942582/ https://www.ncbi.nlm.nih.gov/pubmed/36641750 http://dx.doi.org/10.1016/j.celrep.2023.112004 |