Sulphated penta-galloyl glucopyranoside (SPGG) is glycosaminoglycan mimetic allosteric inhibitor of cathepsin G

OBJECTIVE: Cathepsin G (CatG) is a cationic serine protease with wide substrate specificity. CatG is reported to play a role in several inflammatory pathologies. Thus, we aimed at identifying a potent and allosteric inhibitor of CatG to be used as a platform in further drug development opportunities...

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Detalles Bibliográficos
Autores principales: Al-Horani, Rami A, Afosah, Daniel K, Kar, Srabani, Aliter, Kholoud F, Mottamal, Madhusoodanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942669/
https://www.ncbi.nlm.nih.gov/pubmed/36844783
http://dx.doi.org/10.1093/rpsppr/rqad001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942669/
https://www.ncbi.nlm.nih.gov/pubmed/36844783
http://dx.doi.org/10.1093/rpsppr/rqad001

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