Intranasal delivery of full-length anti-Nogo-A antibody: A potential alternative route for therapeutic antibodies to central nervous system targets

Antibody delivery to the CNS remains a huge hurdle for the clinical application of antibodies targeting a CNS antigen. The blood–brain barrier and blood–CSF barrier restrict access of therapeutic antibodies to their CNS targets in a major way. The very high amounts of therapeutic antibodies that are...

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Detalles Bibliográficos
Autores principales: Correa, Daphne, Scheuber, Myriam I., Shan, Huimin, Weinmann, Oliver W., Baumgartner, Yves A., Harten, Aliona, Wahl, Anna-Sophia, Skaar, Kirstin L., Schwab, Martin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942809/
https://www.ncbi.nlm.nih.gov/pubmed/36649432
http://dx.doi.org/10.1073/pnas.2200057120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942809/
https://www.ncbi.nlm.nih.gov/pubmed/36649432
http://dx.doi.org/10.1073/pnas.2200057120

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