Using heparan sulfate octadecasaccharide (18-mer) as a multi-target agent to protect against sepsis

Sepsis is a lethal syndrome manifested by an unregulated, overwhelming inflammation from the host in response to infection. Here, we exploit the use of a synthetic heparan sulfate octadecasaccharide (18-mer) to protect against sepsis. The 18-mer not only inhibits the pro-inflammatory activity of ext...

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Detalles Bibliográficos
Autores principales: Liao, Yi-En, Xu, Yongmei, Arnold, Katelyn, Zhang, Fuming, Li, Jine, Sellers, Rani, Yin, Chaoyin, Pagadala, Vijayakanth, Inman, Anna Marie, Linhardt, Robert J., Xu, Ding, Pawlinski, Rafal, Liu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942825/
https://www.ncbi.nlm.nih.gov/pubmed/36649428
http://dx.doi.org/10.1073/pnas.2209528120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942825/
https://www.ncbi.nlm.nih.gov/pubmed/36649428
http://dx.doi.org/10.1073/pnas.2209528120

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