A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients

Sex-biased humoral immune responses to COVID-19 patients have been observed, but the cellular basis for this is not understood. Using single-cell proteomics by mass cytometry, we find disrupted regulation of humoral immunity in COVID-19 patients, with a sex-biased loss of circulating follicular regu...

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Detalles Bibliográficos
Autores principales: Søndergaard, Jonas Nørskov, Tulyeu, Janyerkye, Edahiro, Ryuya, Shirai, Yuya, Yamaguchi, Yuta, Murakami, Teruaki, Morita, Takayoshi, Kato, Yasuhiro, Hirata, Haruhiko, Takeda, Yoshito, Okuzaki, Daisuke, Sakaguchi, Shimon, Kumanogoh, Atsushi, Okada, Yukinori, Wing, James Badger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942838/
https://www.ncbi.nlm.nih.gov/pubmed/36669118
http://dx.doi.org/10.1073/pnas.2217902120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942838/
https://www.ncbi.nlm.nih.gov/pubmed/36669118
http://dx.doi.org/10.1073/pnas.2217902120

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