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A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients
Sex-biased humoral immune responses to COVID-19 patients have been observed, but the cellular basis for this is not understood. Using single-cell proteomics by mass cytometry, we find disrupted regulation of humoral immunity in COVID-19 patients, with a sex-biased loss of circulating follicular regu...
Autores principales: | Søndergaard, Jonas Nørskov, Tulyeu, Janyerkye, Edahiro, Ryuya, Shirai, Yuya, Yamaguchi, Yuta, Murakami, Teruaki, Morita, Takayoshi, Kato, Yasuhiro, Hirata, Haruhiko, Takeda, Yoshito, Okuzaki, Daisuke, Sakaguchi, Shimon, Kumanogoh, Atsushi, Okada, Yukinori, Wing, James Badger |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942838/ https://www.ncbi.nlm.nih.gov/pubmed/36669118 http://dx.doi.org/10.1073/pnas.2217902120 |
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