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De novo protein fold design through sequence-independent fragment assembly simulations
De novo protein design generally consists of two steps, including structure and sequence design. Many protein design studies have focused on sequence design with scaffolds adapted from native structures in the PDB, which renders novel areas of protein structure and function space unexplored. We deve...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942881/ https://www.ncbi.nlm.nih.gov/pubmed/36656852 http://dx.doi.org/10.1073/pnas.2208275120 |