AT7867 Inhibits the Growth of Colorectal Cancer Stem-Like Cells and Stemness by Regulating the Stem Cell Maintenance Factor Ascl2 and Akt Signaling

Cancer stem cells (CSCs) are the core factors leading to recurrence, insensitivity to radiotherapy and chemotherapy, and immunotherapy resistance in patients with colorectal cancer. AT7867, a potent oral AKT inhibitor, was found to have antitumor activity in colorectal cancer; however, the effect on...

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Detalles Bibliográficos
Autores principales: Li, Yuchen, Yuan, Yun, Yang, Luyao, Chen, Hongqing, Zhang, Xufan, Wen, Tian, Liao, Wenhao, Zhao, Maoyuan, Zhao, Ziyi, Hu, Qiongying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943616/
https://www.ncbi.nlm.nih.gov/pubmed/36824410
http://dx.doi.org/10.1155/2023/4199052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943616/
https://www.ncbi.nlm.nih.gov/pubmed/36824410
http://dx.doi.org/10.1155/2023/4199052

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