Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis

Advances in DNA sequencing technology and bioinformatics have revealed the enormous potential of microbes to produce structurally complex specialized metabolites with diverse uses in medicine and agriculture. However, these molecules typically require structural modification to optimize them for app...

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Detalles Bibliográficos
Autores principales: Huang, Chuan, Zabala, Daniel, de los Santos, Emmanuel L C, Song, Lijiang, Corre, Christophe, Alkhalaf, Lona M, Challis, Gregory L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943649/
https://www.ncbi.nlm.nih.gov/pubmed/36718812
http://dx.doi.org/10.1093/nar/gkad009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943649/
https://www.ncbi.nlm.nih.gov/pubmed/36718812
http://dx.doi.org/10.1093/nar/gkad009

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