Cargando…

Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis

Advances in DNA sequencing technology and bioinformatics have revealed the enormous potential of microbes to produce structurally complex specialized metabolites with diverse uses in medicine and agriculture. However, these molecules typically require structural modification to optimize them for app...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Chuan, Zabala, Daniel, de los Santos, Emmanuel L C, Song, Lijiang, Corre, Christophe, Alkhalaf, Lona M, Challis, Gregory L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943649/
https://www.ncbi.nlm.nih.gov/pubmed/36718812
http://dx.doi.org/10.1093/nar/gkad009

Ejemplares similares