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Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis
Advances in DNA sequencing technology and bioinformatics have revealed the enormous potential of microbes to produce structurally complex specialized metabolites with diverse uses in medicine and agriculture. However, these molecules typically require structural modification to optimize them for app...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943649/ https://www.ncbi.nlm.nih.gov/pubmed/36718812 http://dx.doi.org/10.1093/nar/gkad009 |