Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding

The introduction of phosphorothioate (PS) linkages to the backbone of therapeutic nucleic acids substantially increases their stability and potency. It also affects their interactions with cellular proteins, but the molecular mechanisms that underlie this effect are poorly understood. Here, we repor...

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Detalles Bibliográficos
Autores principales: Hyjek-Składanowska, Malwina, Anderson, Brooke A, Mykhaylyk, Vitaliy, Orr, Christian, Wagner, Armin, Poznański, Jarosław T, Skowronek, Krzysztof, Seth, Punit, Nowotny, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943651/
https://www.ncbi.nlm.nih.gov/pubmed/36124719
http://dx.doi.org/10.1093/nar/gkac774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943651/
https://www.ncbi.nlm.nih.gov/pubmed/36124719
http://dx.doi.org/10.1093/nar/gkac774

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