Cargando…
Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding
The introduction of phosphorothioate (PS) linkages to the backbone of therapeutic nucleic acids substantially increases their stability and potency. It also affects their interactions with cellular proteins, but the molecular mechanisms that underlie this effect are poorly understood. Here, we repor...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943651/ https://www.ncbi.nlm.nih.gov/pubmed/36124719 http://dx.doi.org/10.1093/nar/gkac774 |