The nucleosome unwrapping free energy landscape defines distinct regions of transcription factor accessibility and kinetics

Transcription factors (TF) require access to target sites within nucleosomes to initiate transcription. The target site position within the nucleosome significantly influences TF occupancy, but how is not quantitatively understood. Using ensemble and single-molecule fluorescence measurements, we inv...

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Detalles Bibliográficos
Autores principales: Donovan, Benjamin T, Luo, Yi, Meng, Zhiyuan, Poirier, Michael G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943653/
https://www.ncbi.nlm.nih.gov/pubmed/36688297
http://dx.doi.org/10.1093/nar/gkac1267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943653/
https://www.ncbi.nlm.nih.gov/pubmed/36688297
http://dx.doi.org/10.1093/nar/gkac1267

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