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The nucleosome unwrapping free energy landscape defines distinct regions of transcription factor accessibility and kinetics
Transcription factors (TF) require access to target sites within nucleosomes to initiate transcription. The target site position within the nucleosome significantly influences TF occupancy, but how is not quantitatively understood. Using ensemble and single-molecule fluorescence measurements, we inv...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943653/ https://www.ncbi.nlm.nih.gov/pubmed/36688297 http://dx.doi.org/10.1093/nar/gkac1267 |