Protein engineering reveals that gasdermin A preferentially targets mitochondrial membranes over the plasma membrane during pyroptosis

When activated, gasdermin family members are thought to be pore-forming proteins that cause lytic cell death. Despite this, numerous studies have suggested that the threshold for lytic cell death is dependent on which gasdermin family member is activated. Determination of the propensity of various g...

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Detalles Bibliográficos
Autores principales: Kondolf, Hannah C., D'Orlando, Dana A., Dubyak, George R., Abbott, Derek W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943860/
https://www.ncbi.nlm.nih.gov/pubmed/36642180
http://dx.doi.org/10.1016/j.jbc.2023.102908

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943860/
https://www.ncbi.nlm.nih.gov/pubmed/36642180
http://dx.doi.org/10.1016/j.jbc.2023.102908

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