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Noncanonical amino acids as doubly bio-orthogonal handles for one-pot preparation of protein multiconjugates

Genetic encoding of noncanonical amino acid (ncAA) for site-specific protein modification has been widely applied for many biological and therapeutic applications. To efficiently prepare homogeneous protein multiconjugates, we design two encodable noncanonical amino acids (ncAAs), 4-(6-(3-azidopropy...

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Detalles Bibliográficos
Autores principales: Wang, Yong, Zhang, Jingming, Han, Boyang, Tan, Linzhi, Cai, Wenkang, Li, Yuxuan, Su, Yeyu, Yu, Yutong, Wang, Xin, Duan, Xiaojiang, Wang, Haoyu, Shi, Xiaomeng, Wang, Jing, Yang, Xing, Liu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944564/
https://www.ncbi.nlm.nih.gov/pubmed/36810592
http://dx.doi.org/10.1038/s41467-023-36658-y