Enhanced mucosal immune responses and reduced viral load in the respiratory tract of ferrets to intranasal lipid nanoparticle-based SARS-CoV-2 proteins and mRNA vaccines

BACKGROUND: Unlike the injectable vaccines, intranasal lipid nanoparticle (NP)-based adjuvanted vaccine is promising to protect against local infection and viral transmission. Infection of ferrets with SARS-CoV-2 results in typical respiratory disease and pathology akin to in humans, suggesting that...

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Detalles Bibliográficos
Autores principales: Boley, Patricia A., Lee, Carolyn M., Schrock, Jennifer, Yadav, Kush Kumar, Patil, Veerupaxagouda, Suresh, Raksha, Lu, Songqing, Feng, Maoqi Mark, Hanson, Juliette, Channappanavar, Rudra, Kenney, Scott P., Renukaradhya, Gourapura J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944789/
https://www.ncbi.nlm.nih.gov/pubmed/36814238
http://dx.doi.org/10.1186/s12951-023-01816-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944789/
https://www.ncbi.nlm.nih.gov/pubmed/36814238
http://dx.doi.org/10.1186/s12951-023-01816-3

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