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The impact of hypoxia and oxidative stress on proteo-metabolomic alterations of 3D cholangiocarcinoma models

The three-dimensional multicellular spheroid (3D MCS) model has been employed in cholangiocarcinoma research as it generates 3D architecture and includes more physiological relevance with the multicellular arrangement. However, it is also essential to explain the molecular signature in this microenv...

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Detalles Bibliográficos
Autores principales: Phukhum, Pimpawadee, Phetcharaburanin, Jutarop, Chaleekarn, Kwuanjira, Kittirat, Yingpinyapat, Kulthawatsiri, Thanaporn, Namwat, Nisana, Loilome, Watcharin, Khuntikeo, Narong, Titapun, Attapol, Wangwiwatsin, Arporn, Khampitak, Tueanjit, Suksawat, Manida, Klanrit, Poramate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944917/
https://www.ncbi.nlm.nih.gov/pubmed/36810897
http://dx.doi.org/10.1038/s41598-023-30204-y