Impairment of β-adrenergic regulation and exacerbation of pressure-induced heart failure in mice with mutations in phosphoregulatory sites in the cardiac Ca(V)1.2 calcium channel

The cardiac calcium channel Ca(V)1.2 conducts L-type calcium currents that initiate excitation-contraction coupling and serves as a crucial mediator of β-adrenergic regulation of the heart. We evaluated the inotropic response of mice with mutations in C-terminal phosphoregulatory sites under physiol...

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Detalles Bibliográficos
Autores principales: Hovey, Liam, Guo, Xiaoyun, Chen, Yi, Liu, Qinghang, Catterall, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944942/
https://www.ncbi.nlm.nih.gov/pubmed/36846334
http://dx.doi.org/10.3389/fphys.2023.1049611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944942/
https://www.ncbi.nlm.nih.gov/pubmed/36846334
http://dx.doi.org/10.3389/fphys.2023.1049611

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