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Batch alignment of single-cell transcriptomics data using deep metric learning

scRNA-seq has uncovered previously unappreciated levels of heterogeneity. With the increasing scale of scRNA-seq studies, the major challenge is correcting batch effect and accurately detecting the number of cell types, which is inevitable in human studies. The majority of scRNA-seq algorithms have...

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Detalles Bibliográficos
Autores principales: Yu, Xiaokang, Xu, Xinyi, Zhang, Jingxiao, Li, Xiangjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944958/
https://www.ncbi.nlm.nih.gov/pubmed/36810607
http://dx.doi.org/10.1038/s41467-023-36635-5