Efficacy of clozapine compared with other second-generation antipsychotic drugs in patients with treatment-resistant schizophrenia: protocol for a systematic review and individual patient data meta-analysis of randomised controlled trials

INTRODUCTION: Guidelines recommend clozapine for treatment-resistant schizophrenia. However, meta-analysis of aggregate data (AD) did not demonstrate higher efficacy of clozapine compared with other second-generation antipsychotics but found substantial heterogeneity between trials and variation bet...

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Detalles Bibliográficos
Autores principales: Siafis, Spyridon, Schneider-Thoma, Johannes, Hamza, Tasnim, Bighelli, Irene, Dong, Shimeng, Hansen, Wulf-Peter, Davis, John M, Salanti, Georgia, Leucht, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Mental Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945033/
https://www.ncbi.nlm.nih.gov/pubmed/36810167
http://dx.doi.org/10.1136/bmjopen-2022-064504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945033/
https://www.ncbi.nlm.nih.gov/pubmed/36810167
http://dx.doi.org/10.1136/bmjopen-2022-064504

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