Hidden hydrophobicity impacts polymer immunogenicity

Antibodies against poly(ethylene glycol) (PEG) have been found to be the culprit of side reactions and efficacy loss of a number of PEGylated drugs. Fundamental mechanisms of PEG immunogenicity and design principles for PEG alternatives still have not been fully explored. By using hydrophobic intera...

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Detalles Bibliográficos
Autores principales: Yuan, Zhefan, McMullen, Patrick, Luozhong, Sijin, Sarker, Pranab, Tang, Chenjue, Wei, Tao, Jiang, Shaoyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945064/
https://www.ncbi.nlm.nih.gov/pubmed/36845929
http://dx.doi.org/10.1039/d2sc07047b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945064/
https://www.ncbi.nlm.nih.gov/pubmed/36845929
http://dx.doi.org/10.1039/d2sc07047b

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