Decreased synaptic vesicle glycoprotein 2A binding in a rodent model of familial Alzheimer's disease detected by [(18)F]SDM-16

INTRODUCTION: Synapse loss is one of the hallmarks of Alzheimer's disease (AD) and is associated with cognitive decline. In this study, we tested [(18)F]SDM-16, a novel metabolically stable SV2A PET imaging probe, in the transgenic APPswe/PS1dE9 (APP/PS1) mouse model of AD and age-matched wild-...

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Detalles Bibliográficos
Autores principales: Zheng, Chao, Toyonaga, Takuya, Chen, Baosheng, Nicholson, LaShae, Mennie, William, Liu, Michael, Spurrier, Joshua, Deluca, Kristin, Strittmatter, Stephen M., Carson, Richard E., Huang, Yiyun, Cai, Zhengxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945093/
https://www.ncbi.nlm.nih.gov/pubmed/36846134
http://dx.doi.org/10.3389/fneur.2023.1045644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945093/
https://www.ncbi.nlm.nih.gov/pubmed/36846134
http://dx.doi.org/10.3389/fneur.2023.1045644

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