Impact of Chronotherapy on 6-Mercaptopurine Metabolites in Inflammatory Bowel Disease: A Pilot Crossover Trial

Chronotherapy is the timing of medication according to biological rhythms of the host to optimize drug efficacy and minimize toxicity. Efficacy and myelosuppression of azathioprine/6-mercaptopurine (AZA/6-MP) are correlated with the metabolite 6-thioguanine, while the metabolite 6-methylmercaptopuri...

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Detalles Bibliográficos
Autores principales: Swanson, Garth R., Biglin, Mary, Raff, Hannah, Chouhan, Vijit, Jochum, Sarah, Shaikh, Maliha, Francey, Lauren, Bishehsari, Faraz, Hogenesch, John, Keshavarzian, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945554/
https://www.ncbi.nlm.nih.gov/pubmed/36730289
http://dx.doi.org/10.14309/ctg.0000000000000549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945554/
https://www.ncbi.nlm.nih.gov/pubmed/36730289
http://dx.doi.org/10.14309/ctg.0000000000000549

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