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PINK1 protects against dendritic cell dysfunction during sepsis through the regulation of mitochondrial quality control

BACKGROUND: Dendritic cell (DC) dysfunction plays a central role in sepsis-induced immunosuppression. Recent research has indicated that collective mitochondrial fragmentation contributes to the dysfunction of immune cells observed during sepsis. PTEN-induced putative kinase 1 (PINK1) has been chara...

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Detalles Bibliográficos
Autores principales: Wu, You, Chen, Longwang, Qiu, Zhimin, Zhang, Xijing, Zhao, Guangju, Lu, Zhongqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945621/
https://www.ncbi.nlm.nih.gov/pubmed/36809929
http://dx.doi.org/10.1186/s10020-023-00618-5