X-ray structure of human aldo–keto reductase 1C3 in complex with a bile acid fused tetrazole inhibitor: experimental validation, molecular docking and structural analysis

Aldo–keto reductase 1C3 (AKR1C3) catalyzes the reduction of androstenedione to testosterone and reduces the effectiveness of chemotherapeutics. AKR1C3 is a target for treatment of breast and prostate cancer and AKR1C3 inhibition could be an effective adjuvant therapy in the context of leukemia and o...

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Detalles Bibliográficos
Autores principales: Marinović, Maja A., Bekić, Sofija S., Kugler, Michael, Brynda, Jiří, Škerlová, Jana, Škorić, Dušan Đ., Řezáčová, Pavlína, Petri, Edward T., Ćelić, Andjelka S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945864/
https://www.ncbi.nlm.nih.gov/pubmed/36846371
http://dx.doi.org/10.1039/d2md00387b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945864/
https://www.ncbi.nlm.nih.gov/pubmed/36846371
http://dx.doi.org/10.1039/d2md00387b

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