SARS-CoV-2 evolution influences GBP and IFITM sensitivity

SARS-CoV-2 spike requires proteolytic processing for viral entry. A polybasic furin-cleavage site (FCS) in spike, and evolution toward an optimized FCS by dominant variants of concern (VOCs), are linked to enhanced infectivity and transmission. Here we show interferon-inducible restriction factors G...

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Detalles Bibliográficos
Autores principales: Mesner, Dejan, Reuschl, Ann-Kathrin, Whelan, Matthew V. X., Bronzovich, Taylor, Haider, Tafhima, Thorne, Lucy G., Ragazzini, Roberta, Bonfanti, Paola, Towers, Greg J., Jolly, Clare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945951/
https://www.ncbi.nlm.nih.gov/pubmed/36693093
http://dx.doi.org/10.1073/pnas.2212577120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945951/
https://www.ncbi.nlm.nih.gov/pubmed/36693093
http://dx.doi.org/10.1073/pnas.2212577120

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