Unveiling mutation effects on the structural dynamics of the main protease from SARS-CoV-2 with hybrid simulation methods

The main protease of SARS-CoV-2 (called M(pro) or 3CL(pro)) is essential for processing polyproteins encoded by viral RNA. Several M(pro) mutations were found in SARS-CoV-2 variants, which are related to higher transmissibility, pathogenicity, and resistance to neutralization antibodies. Macromolecu...

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Detalles Bibliográficos
Autores principales: Gasparini, P., Philot, E.A., Pantaleão, S.Q., Torres-Bonfim, N.E.S.M., Kliousoff, A., Quiroz, R.C.N., Perahia, D., Simões, R.P., Magro, A.J., Scott, A.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945984/
https://www.ncbi.nlm.nih.gov/pubmed/36870228
http://dx.doi.org/10.1016/j.jmgm.2023.108443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945984/
https://www.ncbi.nlm.nih.gov/pubmed/36870228
http://dx.doi.org/10.1016/j.jmgm.2023.108443

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