Pharmacokinetics and Pharmacodynamics of a Novel Vancomycin Derivative LYSC98 in a Murine Thigh Infection Model Against Staphylococcus aureus

INTRODUCTION: LYSC98 is a novel vancomycin derivative used for gram-positive bacterial infections. Here we compared the antibacterial activity of LYSC98 with vancomycin and linezolid in vitro and in vivo. Besides, we also reported the pharmacokinetic/pharmacodynamic (PK/PD) index and efficacy-target...

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Detalles Bibliográficos
Autores principales: He, Peng, Li, Xin, Guo, Xiaohan, Bian, Xingchen, Wang, Rui, Wang, Yue, Huang, Sijing, Qi, Mengya, Liu, Yuanxia, Feng, Meiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946004/
https://www.ncbi.nlm.nih.gov/pubmed/36845018
http://dx.doi.org/10.2147/IDR.S399150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946004/
https://www.ncbi.nlm.nih.gov/pubmed/36845018
http://dx.doi.org/10.2147/IDR.S399150

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