Cargando…

Pharmacokinetics and Pharmacodynamics of a Novel Vancomycin Derivative LYSC98 in a Murine Thigh Infection Model Against Staphylococcus aureus

INTRODUCTION: LYSC98 is a novel vancomycin derivative used for gram-positive bacterial infections. Here we compared the antibacterial activity of LYSC98 with vancomycin and linezolid in vitro and in vivo. Besides, we also reported the pharmacokinetic/pharmacodynamic (PK/PD) index and efficacy-target...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Peng, Li, Xin, Guo, Xiaohan, Bian, Xingchen, Wang, Rui, Wang, Yue, Huang, Sijing, Qi, Mengya, Liu, Yuanxia, Feng, Meiqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946004/ https://www.ncbi.nlm.nih.gov/pubmed/36845018 http://dx.doi.org/10.2147/IDR.S399150

Ejemplares similares

Synergy between Vancomycin and Nafcillin against Staphylococcus aureus in an In Vitro Pharmacokinetic/Pharmacodynamic Model
por: Leonard, Steven N.
Publicado: (2012)

Antimicrobial pharmacodynamics of vancomycin and disulfiram (Antabuse®) in Staphylococcus aureus
por: Chavva, Hasitha, et al.
Publicado: (2023)

In vivo Pharmacodynamic Evaluation of Omadacycline (PTK 0796) against Staphylococcus aureus (SA) in the Murine Thigh Infection Model
por: Lepak, Alexander J, et al.
Publicado: (2017)

395 Impact of vancomycin pharmacokinetic/pharmacodynamic data on clinical outcomes of methicillin-resistant Staphylococcus aureus bacteremia in children
por: Yoo, Reenar, et al.
Publicado: (2014)

Pharmacokinetics and Pharmacodynamics of Nemonoxacin in a Neutropenic Murine Lung Infection Model Against Streptococcus Pneumoniae
por: Li, Xin, et al.
Publicado: (2021)

Pharmacokinetics/pharmacodynamics of lefamulin in a neutropenic murine pneumonia model with Staphylococcus aureus and Streptococcus pneumoniae
por: Wicha, Wolfgang W, et al.
Publicado: (2019)

Murine Thigh Microdialysis to Evaluate the Pharmacokinetic/Pharmacodynamic Integration of Cefquinome Against Actinobacillus pleuropneumoniae
por: Zhang, Longfei, et al.
Publicado: (2020)

Pharmacokinetics and pharmacodynamics of enrofloxacin treatment of Escherichia coli in a murine thigh infection modeling
por: Liu, Xuesong, et al.
Publicado: (2021)

Dalbavancin, Vancomycin and Daptomycin Alone and in Combination with Cefazolin against Resistant Phenotypes of Staphylococcus aureus in a Pharmacokinetic/Pharmacodynamic Model
por: Abdul-Mutakabbir, Jacinda C., et al.
Publicado: (2020)

Impact of initial vancomycin pharmacokinetic/pharmacodynamic parameters on the clinical and microbiological outcomes of methicillin-resistant Staphylococcus aureus bacteremia in children
por: Yoo, Reenar, et al.
Publicado: (2021)

Transportan 10 improves the pharmacokinetics and pharmacodynamics of vancomycin
por: Ruczyński, Jarosław, et al.
Publicado: (2019)

1264. Assessment of In Vivo Efficacy of CF-296 in addition to Vancomycin (VAN) and Daptomycin (DAP) against Staphylococcus aureus in the Neutropenic Murine Thigh Infection Model
por: Asempa, Tomefa E, et al.
Publicado: (2020)

Vancomycin Resistance in Staphylococcus aureus 
por: McGuinness, Will A., et al.
Publicado: (2017)

1560. Pharmacokinetics–Pharmacodynamics (PK-PD) of Gepotidacin (GEP) Against Escherichia coli in Murine Pyelonephritis and Thigh Infection Models
por: Barth, Aline, et al.
Publicado: (2019)

Dose Assessment of Cefquinome by Pharmacokinetic/Pharmacodynamic Modeling in Mouse Model of Staphylococcus aureus Mastitis
por: Yu, Yang, et al.
Publicado: (2016)

Pharmacokinetics and Pharmacodynamics (PK/PD) of Corallopyronin A against Methicillin-Resistant Staphylococcus aureus
por: Rox, Katharina, et al.
Publicado: (2022)

Publisher Correction: Transportan 10 improves the pharmacokinetics and pharmacodynamics of vancomycin
por: Ruczyński, Jarosław, et al.
Publicado: (2019)

Comparison of In Vivo Pharmacokinetics and Pharmacodynamics of Vancomycin Products Available in Korea
por: Kim, Hee Kyung, et al.
Publicado: (2020)

Reduced Susceptibility to Vancomycin in Staphylococcus aureus
por: Mimica, Marcelo J.
Publicado: (2011)

Evaluating vancomycin susceptibility in Staphylococcus aureus
por: Mimica, Marcelo J, et al.
Publicado: (2016)

Determination of Vancomycin-resistant Staphylococcus aureus
por: Ghasabi, Farzane, et al.
Publicado: (2017)

Vancomycin Resistance in Enterococcus and Staphylococcus aureus
por: Li, Gen, et al.
Publicado: (2022)

Neutropenic Rat Thigh Infection Model for Evaluation of the Pharmacokinetics/Pharmacodynamics of Anti-Infectives
por: Yedle, Randhir, et al.
Publicado: (2023)

Pharmacokinetic/Pharmacodynamic Based Breakpoints of Polymyxin B for Bloodstream Infections Caused by Multidrug-Resistant Gram-Negative Pathogens
por: Bian, Xingchen, et al.
Publicado: (2022)

Characterization of Infections with Vancomycin-Intermediate Staphylococcus aureus (VISA) and Staphylococcus aureus with Reduced Vancomycin Susceptibility in South Korea
por: Park, Jung Wan, et al.
Publicado: (2019)

Pharmacokinetics, pharmacodynamics and efficacy of novel FabI inhibitor AFN-1252 against MSSA and MRSA in the murine thigh infection model
por: Banevicius, Mary A, et al.
Publicado: (2013)

Pharmacokinetics and Pharmacodynamics of Fungal Defensin NZX Against Staphylococcus aureus-Induced Mouse Peritonitis Model
por: Zheng, Xueling, et al.
Publicado: (2022)

973. Pharmacokinetic/Pharmacodynamic Evaluation and Dose Optimization of Daptomycin in Pediatric Patients with Staphylococcus aureus Bacteremia
por: Olney, Katie B, et al.
Publicado: (2023)

Pharmacokinetic, Pharmacokinetic/Pharmacodynamic, and Safety Investigations of Lefamulin in Healthy Chinese Subjects
por: Hu, Yingying, et al.
Publicado: (2023)

Pharmacodynamics of vancomycin in elderly patients aged 75 years or older with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia
por: Mizokami, Fumihiro, et al.
Publicado: (2013)

Pharmacodynamic comparison of different antimicrobial regimens against Staphylococcus aureus bloodstream infections with elevated vancomycin minimum inhibitory concentration
por: da Costa, Thaina Miranda, et al.
Publicado: (2020)

Pharmacokinetic/pharmacodynamic parameters of vancomycin for predicting clinical outcome of enterococcal bacteremia
por: Nham, Eliel, et al.
Publicado: (2022)

Molecular Events for Promotion of Vancomycin Resistance in Vancomycin Intermediate Staphylococcus aureus
por: Hu, Qiwen, et al.
Publicado: (2016)

Draft Genome Sequences of Vancomycin-Susceptible Staphylococcus aureus Related to Heterogeneous Vancomycin-Intermediate S. aureus
por: Ramaraj, Thiruvarangan, et al.
Publicado: (2014)

In Vivo Pharmacokinetics/Pharmacodynamics of Cefquinome in an Experimental Mouse Model of Staphylococcus Aureus Mastitis following Intramammary Infusion
por: Yu, Yang, et al.
Publicado: (2016)

Pharmacokinetic/Pharmacodynamic Correlation of Cefquinome Against Experimental Catheter-Associated Biofilm Infection Due to Staphylococcus aureus
por: Zhou, Yu-Feng, et al.
Publicado: (2016)

Reconstruction of the Vancomycin-Susceptible Staphylococcus aureus Phenotype From a Vancomycin-Intermediate S. aureus XN108
por: Peng, Huagang, et al.
Publicado: (2018)

Complete Reconstitution of the Vancomycin-Intermediate Staphylococcus aureus Phenotype of Strain Mu50 in Vancomycin-Susceptible S. aureus
por: Katayama, Yuki, et al.
Publicado: (2016)

Pharmacokinetic/Pharmacodynamic Target Attainment of Vancomycin, at Three Reported Infusion Modes, for Methicillin-Resistant Staphylococcus aureus (MRSA) Bloodstream Infections in Critically Ill Patients: Focus on Novel Infusion Mode
por: Song, Xiangqing, et al.
Publicado: (2022)

Resistance and Molecular Characteristics of Methicillin-Resistant Staphylococcus aureus and Heterogeneous Vancomycin-Intermediate Staphylococcus aureus
por: Liang, Jin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_uae72458hjmb29sg17lbr07bsp